Publications

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No. Authors Title Publication Date Link
1 K. Konstantopoulos, K.K. Wu, M.M. Udden, E.I. Banez, S.J. Shattil, J.D. Hellums Flow Cytometric Studies of Platelet Response to Shear Stress in Whole Blood Biorheology 1995 link
2 K. Konstantopoulos, S.G. Kamat, A.I. Schafer, E.I. Banez, R. Jordan, N.L. Kleiman, J.D. Hellums Shear-Induced Platelet Aggregation is Inhibited by In Vivo Infusion of an Anti-Glycoprotein IIb/IIa Antibody Fragment, c7E3 Fab, in Patients Undergoing Coronary Angioplasty Circulation 1995 link
3 K. Konstantopoulos, J.C. Grotta, C. Sills, K.K. Wu, J.D. Hellums Shear-Induced Platelet Aggregation in Normal Subjects and Stroke Patients Thrombosis & Haemostasis 1995 link
4 K. Konstantopoulos, L.V. McIntire Effects of Fluid Dynamic Forces on Vascular Cell Adhesion Journal of Clinical Investigation 1996 link
5 S.G. Kamat, N.A. Turner, K. Konstantopoulos, J.D. Hellums, L.V. McIntire, N.S. Kleiman, J.L. Moake Effects of Integrelin on Models of Arterial Thrombosis Journal of Cardiovascular Pharmacology 1997 link
6 K. Konstantopoulos, S. Kukreti, C.W. Smith, L.V. McIntire Endothelial P-selectin and VCAM-1 Each Can Function as Primary Adhesive Mechanisms for T Cells Under Conditions of Flow Journal of Leukocyte Biology 1997 link
7 K. Konstantopoulos, T.W. Chow, N.A. Turner, J.D. Hellums, J.L. Moake Shear Stress-Induced Binding of von Willebrand Factor to Platelets Biorheology 1997 link
8 S. Kukreti, K. Konstantopoulos, C.W. Smith, L.V. McIntire Molecular Mechanisms of Monocyte Adhesion to IL-1Beta Stimulated Endothelial Cells Under Physiological Flow Conditions Blood 1997 link
9 K. Konstantopoulos and L.V. McIntire Effects of Fluid Dynamic Forces on Vascular Cell Adhesion Journal of Clinical Investigation 1997 link
10 S. Kukreti, K. Konstantopoulos, L.V. McIntire Cell-Cell Interactions Frontiers in Tissue Engineering 1998 link
11 K. Konstantopoulos, S. Neelamegham, A.R. Burns, E. Hentzen, G.S. Kansas, K.R. Snapp, E.L. Berg, J.D. Hellums, C.W. Smith, L.V. McIntire, S.I. Simon Venous Levels of Shear Support Neutrophil-Platelet Adhesion and Neutrophil Aggregation in Blood via P-Selectin and Beta2-Integrin Circulation 1998 link
12 K. Konstantopoulos, S. Kukreti, L.V. McIntire Biomechanics of Cell Interactions in Shear Fields Advanced Drug Delivery Reviews 1998 link
13 M.N.B. Papadimitriou, D.G. Menter, K. Konstantopoulos, G.L. Nicolson, L.V. McIntire Integrin alpha4beta1/VCAM-1 Pathway Mediates Primary Adhesion of RAW 117 Lymphoma Cells to Hepatic Sinusoidal Endothelial Cells Under Flow Clinical & Experimental Metastasis 1999 link
14 H. Tachimoto, M.M. Burdick, S.A. Hudson, M. Kikuchi, K. Konstantopoulos, B.S. Bochner CCR3-active Chemokines Promote Rapid Detachment of Eosinophils from VCAM-1 In Vitro Journal of Immunology 2000 link
15 O.J.T. McCarty, S.A. Mousa, P.F. Bray, K. Konstantopoulos Immobilized Platelets Support Human Colon Carcinoma Cell Tethering, Rolling and Firm Adhesion Under Dynamic Flow Conditions Blood 2000 link
16 J.P. Abulencia, N. Tien, O.J.T. McCarty, D. Plymire, S.A. Mousa, K. Konstantopoulos Comparative Antiplatelet Efficacy of a Novel Nonpeptide GPIIb/IIIa Antagonist (XV454) and Abciximab (c7E3) in Flow Models of Thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology 2001 link
17 M.M. Burdick, R.L. Schnaar, B.E. Collins, B.S. Bochner, K. Konstantopoulos Glycolipids Support E-selectin-Specific Strong Cell Tethering under Flow Biochemical and Biophysical Research Communications 2001 link
18 M.M. Burdick, O.J.T. McCarty, S. Jadhav, K. Konstantopoulos Cell-Cell Interactions in Inflammation and Cancer Metastasis IEEE Engineering in Medicine and Biology 2001 link
19 K. Konstantopoulos, S.A. Mousa Antiplatelet Therapies: Platelet GPIIb/IIa Antagonists & Beyond Current Opinion in Investigational Drugs 2001 link
20 S. Jadhav, B.S. Bochner, K. Konstantopoulos Hydrodynamic Shear Regulates the Kinetics and Receptor Specificity of Polymorphonuclear Leukocyte-Colon Carcinoma Cell Adhesive Interactions Journal of Immunology 2001 link
21 S.A. Mousa, K. Konstantopoulos, R. Giugliano Oral Antiplatelet Therapies Beyond Aspirin and Thienopyridines Therapeutic Agents for Thrombosis and Thrombolysis: Second Edition 2002 no link
22 S.A. Mousa, J.P. Abulencia, O.J.T. McCarty, N.A. Turner, K. Konstantopoulos Comparative Efficacy Between the GPIIb/IIIa Antagonists, Roxifiban and Orbofiban, in Inhibiting Platelet Function in Flow Models of Thrombosis Journal of Cardiovascular Pharmacology 2002 link
23 O.J.T. McCarty, S. Jadhav, M.M. Burdick, W.R. Bell, K. Konstantopoulos Fluid Shear Regulates the Kinetics and Molecular Mechanisms of Activation-Dependent Platelet Binding to Colon Carcinoma Cells Biophysical Journal 2002 link
24 S. Jadhav, K. Konstantopoulos Fluid Shear- and Time-Dependent Modulation of Molecular Interactions Between Polymorphonuclear Leukocytes and Colon Carcinomas American Journal of Physiology - Cell Physiology 2002 link
25 W.D. Hanley, O.J.T. McCarty, S. Jadhav, Y. Tseng, D. Wirtz, K. Konstantopoulos Single-Molecule Characterization of P-selectin/Ligand Binding Journal of Biological Chemistry 2003 link
26 M.M. Burdick, J.M. McCaffery, Y.S. Kim, B.S. Bochner, K. Konstantopoulos Colon Carcinoma Cell Glycolipids, Integrins, and other Glycoproteins Mediate Adhesion to HUVECs Under Flow American Journal of Physiology - Cell Physiology 2003 link
27 O.J.T. McCarty, N. Tien, B.S. Bochner, K. Konstantopoulos Exogenous Eosinophil Activation Converts PSGL-1-Dependent Binding to CD18-Dependent Stable Adhesion to Platelets in Shear Flow American Journal of Physiology - Cell Physiology 2003 link
28 J.P. Abulencia, R. Gaspard, Z.R. Healy, W.A. Gaarde, J. Quackenbush, K. Konstatopoulos Shear-Induced Cyclooxygenase-2 via a JNK2/c-jun-dependent Pathway Regulates Prostaglandin Receptor Expression in Chondrocytic Cells Journal of Biological Chemistry 2003 link
29 K. Konstantopoulos, W.D. Hanley, D. Wirtz Receptor/Ligand Binding: ‘Catch’ Bonds Finally Caught Current Biology 2003 link
30 O.J.T. McCarty, J.P. Abulencia, S.A. Mousa, K. Konstantopoulos Evaluation of GPIIb/IIIa Antagonists in In-Vitro Flow Models of Thrombosis Methods in Molecular Medicine 2004 link
31 W.D. Hanley, D. Wirtz, K. Konstantopoulos Distinct Kinetic and Mechanical Properties Govern Selectin-Leukocyte Interactions Journal of Cell Science 2004 link
32 P. Pawar, P.K. Shin, S.A. Mousa, J.M. Ross, K. Konstantopoulos Fluid Shear Regulates the Kinetics and Receptor Specificity of Staphylococcus Auerus Binding to Activated Platelets Journal of Immunology 2004 link
33 M.M. Burdick, K. Konstantopoulos Platelet-Induced Enhancement of Colon Carcinoma Cell Adhesion to Vascular Endothelium Under Flow American Journal of Physiology - Cell Physiology 2004 link
34 S. Jadhav, C.D. Eggleton, K. Konstantopoulos A 3D Computational Model Predicts that Cell Deformation Affects Receptor-Ligand Bond Lifetime and Number of Bonds During Rolling Under Shear Biophysical Journal 2005 link
35 K.C. Ahn, A.J. Jun, P. Pawar, S. Jadhav, S. Napier, O.J. McCarty, K. Konstantopoulos Preferential Binding of Platelets to Monocytes Over Neutrophils Under Flow Biochemical and Biophysical Research Communications 2005 link
36 W.D. Hanley, M.M. Burdick, K. Konstantopoulos, R. Sackstein CD44 on LS174T Colon Carcinoma Cells Possess E-Selectin Ligand Activity Cancer Research 2005 link
37 P.K. Shin, P. Pawar, K. Konstantopoulos, J.M. Ross Characteristics of a New Staphylococcus aureus-RBC Adhesion Mechanism Independent of Fibrinogen and Immunoglobulin G under Hydronamic Shear Conditions American Journal of Physiology - Cell Physiology 2005 link
38 Z.R. Healy, N.H. Lee, X. Gao, M.B. Goldring, P. Talalay, T.W. Kensler, K. Konstantopoulos Divergent Responses of Chondrocytes and Endothelial Cells to Shear Stress: Cross-Talk Among COX-2, the Phase 2 Response, and Apoptosis Proceedings of the National Academy of Sciences 2005 link
39 P. Panorchan, M.S. Travis, K. Davis, Y. Tseng, K. Konstantopoulos, D. Wirtz Single-Molecule Analysis of Cadherin-mediated Cell-Cell Adhesion Journal of Cell Science 2006 link
40 W.D. Hanley, S. Napier, M.M. Burdick, R.L. Schnaar, R. Sackstein, K. Konstantopoulos Variant CD44 Isoforms are the P- and L-Selectin Ligands on Colon Carcinomas The FASEB Journal 2006 link
41 A. Grazioli, C. Alves, K. Konstantopoulos, J.T. Yang Defective Blood Vessel Development and Pericyte/pvSMC Distribution in Alpha 4 Integrin-Deficient Mouse Embryos Developmental Biology 2006 link
42 L.H.-K. Lim, M.M. Burdick, S.A. Hudson, K. Konstantopoulos, B.S. Bochner Stimulation of Human Endothelium with IL-3 Induces Selective Basophil Accumulation in Vitro Journal of Immunology 2006 link
43 N.P.E. George, Q. Wei, P.K. Shin, K. Konstantopoulos, J.M. Ross Staphylococcus aureus Adhesion via Spa, ClfA and SdrCDE to Immobilized Platelets Demonstrates Shear Dependent Behavior Arteriosclerosis, Thrombosis, and Vascular Biology 2006 link
44 P. Jaluria, K. Konstantopoulos, M. Betenbaugh, J. Shiloach A Perspective on Microarrays: Current Applications, Pitfalls and Potential Uses Microbial Cell Factories 2007 link
45 S.L. Napier, Z.R. Healy, R.L. Schnaar, K. Konstantopoulos Selectin Ligand Expression Regulates the Initial Vascular Interactions of Colon Carcinoma Cells, The Roles of CD44v an Alternate Sialofucosylated Selectin Ligands Journal of Biological Chemistry 2007 link
46 S. Jadhav, C.D. Eggleton, K. Konstantopoulos Mathematical Modeling of Cell Adhesion in Shear Flow Pertinent to Inflammation and Cancer Metastasis Current Pharmaceutical Design 2007 link
47 N.P.E. George, K. Konstantopoulos, J.M. Ross Differential Kinetics and Molecular Recognition Mechanisms Involved in Early Versus Late Growth Phase S. aureus Cell Binding to Platelets Under Physiological Shear Conditions Journal of Infectious Diseases 2007 link
48 P. Jaluria, M.J. Betenbaugh, K. Konstantopoulos, B. Frank, J. Shiloach The Use of Microarrays to Identify Genes Involved in Adhesion in HeLa Cells and Subsequent Characterization Metabolic Engineering 2007 link
49 S. Jadhav, K.Y. Chan, K. Konstantopoulos, C.D. Eggleton Shear-Induced Modulation of Intercellular Contact Area Between Two Deformable Cells Colliding Under Flow Journal of Biomechanics 2007 link
50 P. Jaluria, M.J. Betenbaugh, K. Konstantopoulos, J. Shiloach Enhancement of Cell Proliferation and Protein Production in Various Mammalian Cell Lines by Gene Insertion of a Cyclin-dependent Kinase Homolog, cdk13 BMC Biotechnology 2007 link
51 C.S. Alves, M.M. Burdick, S.L. Napier, P. Pawar, K. Konstantopoulos The Dual Role of CD44 as a Functional P-selectin Ligand and Fibrin Receptor in Colon Carcinoma Cell Adhesion The American Journal of Physiology, Cell Physiology 2008 link
52 Z.R. Healy, F. Zhu, J.D. Stull, K. Konstantopoulos Elucidation of the Signaling Network of Cyclooxygenase-2 (COX-2) Induction in Sheared Chondrocytes: COX-2 is Induced Via a Rac/MEKK1/MKK7/JNK2/C-Jun-C/EBPBeta-Dependent Pathway The American Journal of Physiology, Cell Physiology 2008 link
53 S.N. Thomas, F. Zhu, R.L. Schnaar, C.S. Alves, K. Konstantopoulos Carcinoembryonic Antigen and CD44v Cooperate to Mediate Colon Carcinoma Cell Adhesion to E- and L-selectin in Shear Flow Journal of Biological Chemistry 2008 link
54 L. Nimrichter, M.M. Burdick, K. Aoki, W. Laroy, M.A. Fierro, S.A. Hudson, C.E. Von Seggern, R.J. Cotter, B.S. Bochner, M. Tiemeyer, K. Konstantopoulos, R.L. Schnaar E-selectin Receptors on Human Leukocytes Blood 2008 link
55 M. Ghosh, C.S. Alves, Z. Tong, K. Tettey, K. Konstantopoulos, K. Stebe Multi-Functional Surfaces with Discrete Functionalized Regions for Biological Applications Langmuir 2008 link
56 D. Dikeman, L.A. Rivera Rosado, T. Horn, C.S. Ales, K. Konstantopoulos, J.T. Yang alpha4-beta1-Integrin Regulates Directionally Persistent Cell Migration in Response to Shear Flow Stimulation The American Journal of Physiology, Cell Physiology 2008 link
57 P. Jaluria, K. Konstantopoulos, M.J. Betenbaugh, J. Shiloach Egr1 and Gas6 Facilitate the Adaptation of HEK-293 Cells to Serum-Free Media by Conferring Enhanced Viability and Higher Growth Rates Biotechnology & Bioengineering 2008 link
58 P. Pawar, S. Jadhav, C.D. Eggleton, K. Konstantopoulos The Roles of Cell and Microvillus Deformation and Receptor-Ligand Binding Kinetics in Cell Rolling The American Journal of Physiology, Heart and Circulatory Physiology 2008 link
59 T. Dobrowsky, P. Panorchan, K. Konstantopoulos, D. Wirtz Live-cell Single-molecule Force Spectroscopy Methods in Cell Biology 2008 link
60 C.S. Alves, S. Yakovlyev, L. Medved, K. Konstantopoulos Biomolecular Characterization of CD44-fibrin(ogen) Binding: Distinct Molecular Requirements Mediate Binding of Standard and Variant Isoforms of CD44 to Immobilized Fibrin(ogen) Journal of Biological Chemistry 2009 link
61 N.P.E. George, P. Ymele-leki, K. Konstantopoulos, J.M. Ross Differential Binding of Biofilm-Derived Versus Suspension Grown Staphylococcus auereus to Immobilized Platelets in Shear Flow Journal of Infectious Diseases 2009 link
62 S.N. Thomas, R.L. Schnaar, K. Konstantopoulos Podocalyxin-like Protein is a Novel E- and L-, but Not P-, selectin Ligand on Colon Carcinoma Cells: Comparative Biochemical Properties of Selectin Ligands in Normal and Malignant Cells The American Journal of Physiology, Cell Physiology 2009 link
63 S.N. Thomas, Z. Tong, K. Stebe, K. Konstantopoulos Identification, Characterization, and Utilization of Tumor Cell Selectin Ligands in the Design of Cancer Diagnostics Biorheology 2009 link
64 K. Konstantopoulos, S.N. Thomas Cancer Cells In Transit: The Vascular Interactions of Tumor Cells Annual Review of Biomedical Engineering 2009 link
65 F. Zhu, P. Wang, A. Kontrogianni-Konstantopoulos, K. Konstantopoulos Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), Mediate Shear-Induced Chondrocyte Apoptosis via Protein Kinase A-dependent Regulation of Polo-like Kinases Cell Death & Differentiation 2010 link
66 V.K. Gupta, I. Sraj, K. Konstantopoulos, C.D. Eggleton Multi-scale Simulation of L-selectin-PSGL-1-dependent Homotypic Leukocyte Binding and Rupture Biomechanics and Modeling in Mechanobiology 2010 link
67 P. Wang, F. Zhu, K. Konstantopoulos Prostaglandin E2 Induces Interleukin-6 Expression in Human Chondrocytes via a cAMP/Protein Kinase A- and Phosphatidylinositol 3-Kinase-dependent NF-kB Activation The American Journal of Physiology, Cell Physiology 2010 link
68 P. Wang, F. Zhu, N.H. Lee, K. Konstantopoulos Shear-induced interleukin-6 synthesis in chondrocytes: the roles of E prostanoid (EP)2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-{kappa}B activation Journal of Biological Chemistry 2010 link
69 F. Zhu, P. Wang, N. H. Lee, M.B. Goldring, K. Konstantopoulos Prolonged Application of High Fluid Shear to Chondrocytes Recapitulates Gene Expression Profiles Associated with Osteoarthritis PLoS ONE 2010 link
70 L.S-L. Cheung, P.S. Raman, E.M. Balzer, D. Wirtz and K. Konstantopoulos Biophysics of Selectin-Ligand Interactions in Inflammation and Cancer Physical Biology 2011 link
71 K. Konstantopoulos, S.N. Thomas Hematogenous Metastasis: Roles of CD44v and Alternate Sialofucosylated Selectin Ligands Advances in Experimental Medicine and Biology 2011 link
72 P. Sundd, M.K. Pospieszalska, L. S-L. Cheung, K. Konstantopoulos, K. Ley Biomechanics of leukocyte rolling Biorheology 2011 link
73 I. Sraj, K.Y. Chan, K. Konstantopoulos, C. D. Eggleton A Numerical Study of the Influence of Cellular Adhesion on Prestress in Atomic Force Microscopy Measurements Journal of Advanced Microscopy Research 2011 link
74 P.S. Raman, C.S. Alves, D. Wirtz, K. Konstantopoulos Single Molecule Binding of CD44 to Fibrin Versus P-selectin Predicts Their Distinct Shear-dependent Interactions in Cancer Journal of Cell Science 2011 link
75 L. S-L. Cheung, K. Konstantopoulos An analytical model for determining two-dimensional receptor-ligand kinetics Biophysical Journal 2011 link
76 Z. Silva, Z. Tong, M.G. Cabral, C. Martins, R. Castro, C. Reis, H. Trindade, K. Konstantopoulos, P.A. Videira Sialyl Lewisx-dependent Binding of Human Monocyte-derived Dendritic Cells to Selectins Biochemical and Biophysical Research Communications 2011 link
77 D. Wirtz, K. Konstantopoulos, P.C. Searson The physics of cancer: the role of physical interactions and mechanical forces in metastasis Nature Reviews Cancer 2011 link
78 P. Wang, F. Zhu, Z. Tong, K. Konstantopoulos Response of Chondrocytes to Shear Stress: Antogonistic Effects of the Binding Partners Toll-like Receptor 4 and Caveolin-1 The FASEB Journal 2011 link
79 P. Wang, F. Zhu, K. Konstantopoulos Interleukin-6 Synthesis in Human Chondrocytes Is Regulated via the Antagonistic Actions of Prostaglandin (PG)E2 and 15-deoxy-Δ12,14-PGJ2 PLoS ONE 2011 link
80 Z. Tong, E. M. Balzer, M. R. Dallas, W-C. Hung, K. J. Stebe, K. Konstantopoulos Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution PLoS ONE 2012 link
81 L.S-L. Cheung, M. Kanwar, M. Ostermeier, K. Konstantopoulos A Hot Spot Motif Characterizes the Interface Between a Designed Ankyrin-Repeat Protein and Its Target Ligand Biophysical Journal 2012 link
82 S.I. Simon, S. Neelamegham, K. Konstantopoulos Glycomechanics: Sugar Coating Blood Cell-Endothelial Interactions in Shear Flow Annals of Biomedical Engineering 2012 link
83 S-H. Chen, M. R. Dallas, E. M. Balzer, K. Konstantopoulos Mucin 16 is a Functional Selectin Ligand on Pancreatic Cancer Cells The FASEB Journal 2012 link
84 M.R. Dallas, G. Liu, W-C. Chen, S.N. Thomas, D. Wirtz, D.L. Huso, K. Konstantopoulos Divergent Roles of CD44 and Carcinoembryonic Antigen in Colon Carcinoma Metastasis The FASEB Journal 2012 link
85 E. M. Balzer and K. Konstantopoulos Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers WIREs Systems Biology and Medicine 2012 link
86 Z. Silva, K. Konstantopoulos, P. A. Videira The Role of Sugars in Dendritic Cell Trafficking Annals of Biomedical Engineering 2012 link
87 L.S.-L. Cheung, P.S. Raman, D. Wirtz, K. Konstantopoulos Biophysics of Selectin-Mediated Cell-Cell Adhesion Comprehensive Biophysics 2012 link
88 Z. Tong, L.S-L. Cheung, K. J. Stebe, K. Konstantopoulos Selectin-mediated Adhesion in Shear Flow Using Micropatterned Substrates: Multiple-Bond Interactions Govern the Critical Length for Cell Binding Integrative Biology 2012 link
89 R.T. Almaraz, Y. Tian, R. Bhattarcharya, E. Tan, S.H. Chen, M.R, Dallas, L. Chen, Z. Zhang, H. Zhang, K. Konstantopoulos, K.J. Yarema Metabolic Flux Increases Glycoprotein Sialylation: Implications for Cell Adhesion and Cancer Metastasis Molecular and Cellular Proteomics 2012 link
90 P.S. Raman, C.S. Alves, D. Wirtz, K. Konstantopoulos Distinct Kinetic and Molecular Requirements Govern CD44 Binding to Hyaluronan versus Fibrin(ogen) Biophysical Journal 2012 link
91 P. Wang, F. Zhu, K. Konstantopoulos The Antagonistic Actions of Endogenous Interleukin-1Beta and 15-deoxy–Delta-(12,14)-Prostaglandin J2 Regulate the Temporal Synthesis of Matrix Metalloproteinase-9 in Sheared Chondrocytes Journal of Biological Chemistry 2012 link
92 M.R. Dallas, S-H. Chen, M.M. Streppel, S. Sharma, A. Maitra, K. Konstantopoulos Sialofucosylated Podocalyxin is a Functional E- and L-Selectin Ligand Expressed by Metastatic Pancreatic Cancer Cells The American Journal of Physiology, Cell Physiology 2012 link
93 M. M. Streppel, A. Vincent, R. Mukherjee, N. Campbell, S-H. Chen, K. Konstantopoulos, M. G. Goggins, I. Van Seuningen, A. Maitra, E. A. Montgomery MUC16(CA125) Expression in Human Tissues and Cell Lines and Correlation with Clinical Outcome in Adenocarcinomas of the Pancreas, Esophagus, Stomach, and Colon Human Pathology 2012 link
94 E.M. Balzer, Z. Tong, C.D. Paul, W-C Hung, K.M. Stroka, A.E. Boggs, S.E. Martin, K. Konstantopoulos Physical Confinement Alters Tumor Cell Adhesion and Migration Phenotypes The FASEB Journal 2012 link
95 C.S. Alves, K. Konstantopoulos PDGF Suppresses the sulfation of CD44v and Potentiates CD44v-mediated Binding of Colon Carcinoma Cells to Fibrin Under Flow PLoS One 2012 link
96 K.H. Lee, Justin Galloway, J. Park, C. Dvoracek, M. Dallas, K. Konstantopoulos, A. Maitra, P. Searson Quantitative Molecular Profiling of Biomarkers for Pancreatic Cancer with Functionalized Quantum Dots Nanomedicine 2012 link
97 B. Grabias, K. Konstantopoulos Epithelial-Mesenchymal Transition and Fibrosis are Mutually Exclusive Responses in Shear-Activated Proximal Tubular Epithelial Cells The FASEB Journal 2012 link
98 W.-C. Chen, P.-H. Wu, J.M. Phillip, S.B. Khatau, J.M. Choi, M.R. Dallas, K. Konstantopoulos, S.X. Sun, J.S.H. Lee, D. Hodzic, D. Wirtz Functional Interplay between Cell Cycle and Cell Phenotypes Integrative Biology 2013 link
99 K. Konstantopoulos, P.-H. Wu, D. Wirtz Dimensional Control of Cancer Cell Migration Biophysical Journal 2013 link
100 J.A. Bernate, C. Liu, L. Lagae, K. Konstantopoulos, G. Drazer Vector Separation of Particles and Cells using an Array of Slanted Open Cavities Lab on a Chip 2013 link
101 Physical Sciences - Oncology Centers Network A Physical Sciences Network Characterization of Non-tumorigenic and Metastatic Cells Scientific Reports 2013 link
102 S.-H. Chen, W.-C. Hung, P. Wang, C.D. Paul, K. Konstantopoulos Mesothelin Binding to CA125/MUC16 Promotes Pancreatic Cancer Cell Motility and Invasion via MMP-7 Activation Scientific Reports 2013 link
103 B. Grabias, K. Konstantopoulos Notch4-dependent Antagonism of Canonical TGF-beta Signaling Defines Unique Temporal Fluctuations of SMAD3 Activity in Sheared Proximal Tubular Epithelial Cells The American Journal of Physiology - Renal Physiology 2013 link
104 P. Wang, P.-P. Guan, C. Guo, F. Zhu, K. Konstantopoulos, Z.-Y. Wang Fluid Shear Stress-Induced Osteoarthritis: Roles of Cyclooxygenase-2 and its Metabolic Products in Inducing the Expression of Proinflammatory Cytokines and Matrix Metalloproteinases The FASEB Journal 2013 link
105 W.-C. Hung, S.-H. Chen, C.D. Paul, K.M. Stroka, Y.-C. Lo, Y.T. Yang, K. Konstantopoulos Distinct Signaling Mechanisms Regulate Migration in Unconfined Versus Confined Spaces Journal of Cell Biology 2013 link
106 P.S. Raman, C.D. Paul, K.M. Stroka, K. Konstantopoulos Probing Cell Traction Forces in Confined Microenvironments Lab on a Chip 2013 link
107 B. Grabias, K. Konstantopoulos The Physical Basis of Renal Fibrosis: Effects of Altered Hydrodynamic Forces on Kidney Homeostasis American Journal of Physiology Renal Physiology 2014 link
108 K.M. Stroka and K. Konstantopoulos Physical Biology in Cancer. 4. Physical Cues Guide Tumor Cell Adhesion and Migration Am J Physiol Cell Physiol. 2014 link
109 K.M. Stroka, H. Jiang, S.-H. Chen, Z. Tong, D. Wirtz, S. Sun, K. Konstantopoulos Water Permeation Drives Tumor Cell Migration in Confined Microenvironments Cell 2014 link
110 P. Wang, P.P. Guan, T. Wang, X. Yu, J.-J. Guo, K. Konstantopoulos, Z.Y Wang Interleukin-1b and Cyclic AMP Mediate the Invasion of Sheared Chondrosarcoma Cells via a Matrix Metalloproteinase-1-Dependent Mechanism BBA Molecular Cell Research 2014 link
111 K.M. Stroka, Z. Gu, S.X. Sean, K. Konstantopoulos Bioengineering paradigms for cell migration in confined microenvironments Current Opinion in Cell Biology 2014 link
112 K. Konstantopoulos and T. Segura Editorial overview: Materials engineering: Advances in smart and controlled delivery of therapeutic molecules Current Opinion in Chemical Engineering 2015 no link
113 L. S.-L. Cheung, D.J. Shea, N. Nicholes, A. Date, M. Ostermeier & K. Konstantopoulos Characterization of Monobody Scaffold Interactions with Ligand via Force Spectroscopy and Steered Molecular Dynamics Scientific Reports 2015 link
114 P.-P. Guan, X. Yu, J-J. Guo, Y. Wang, T. Wang, J.-Y. Li, K. Konstantopoulos, Z.-Y. Wang, P. Wang By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization Oncotarget 2015 link
115 P.-P. Guan, J.-J. Guo, X. Yu, Y. Wang, T. Wang, K. Konstantopoulos, J.-Y. Li, Z.-Y. Wang, P. Wang The role of Cyclooxygenase-2, Interleukin-1ß and Fibroblast Growth Factor-2 in the Activation of Matrix Metalloproteinase-1 in Sheared Chondrocytes and Articular Cartilage Scientific Reports 2015 link
116 D. Shea, D. Wirtz, K.J. Stebe, K. Konstantopoulos Distinct Kinetic and Mechanical Properties Govern Mucin 16- and Podocalyxin- Mediated Tumor Cell Adhesion to E- and L-selectin in Shear Flow Oncotarget 2015 link
117 M. Shriver, K.M. Stroka, M. Vitolo, S. Martin, D.L. Huso, K. Konstantopoulos, A. Kontrogianni-Konstantopoulos Loss of Giant Obscurins from Breast Epithelium Promotes Epithelial-to-Mesenchymal Transition, Tumorigenicity and Metastasis Oncogene 2015 link
118 X. Yu, P.-P. Guan, J.-W. Guo, Y. Wang, L.L. Cao, G.-B. Xu, K. Konstantopoulos, Z.-Y. Wang, P. Wang By Suppressing the Expression of APH-1α and APH-1β, Magnesium Ions Improve the Cognitive Decline of APP/PS1 Transgenic Mice by Inhibiting the Circuits of Amyloid β-protein FASEB J 2015 link
119 P. Wang, S.-H. Chen, W.-C. Hung, C.D. Paul, F. Zhu, P.-P. Guan, D.L. Huso, A. Kontrogianni-Konstantopoulos and K. Konstantopoulos, Fluid Shear Promotes Chondrosarcoma Cell Invasion by Activating Matrix Metalloproteinase-12 via IGF-2- and VEGF-Signaling Pathways Oncogene 2015 link
120 L. He, W. Chen, P.-H. Wu, A. Jimenez, B.S. Wong, A. San, K. Konstantopoulos and D. Wirtz Local 3D matrix confinement determines division axis through cell shape Oncotarget 2015 link
121 D.J. Zabranskya, C.L. Yankaskas, R.L. Cochran, H.Y. Wong, S. Croessmann, D. Chu, S.M. Kavuri, M.R. Brewer, D.M. Rosen, W.B. Dalton, A. Cimino-Mathews, K. Cravero, B. Button, K. Kyker-Snowman, J. Cidado, B. Erlanger, H. Parsons, K.M. Manto, R. Bose, J. Lauring, C.L. Arteaga, K. Konstantopoulos, B.H. Park HER2 missense mutations have distinct effects on oncogenic signaling and migration PNAS 2015 link
122 C.D. Paul, W.-C. Hung, D. Wirtz and K. Konstantopoulos Engineered Models of Confined Cell Migration Annual Review of Biomedical Engineering 2016 link
123 C.D. Paul, D.J. Shea, M.R. Mahoney, A. Chai, V. Laney, W.-C. Hung, and K. Konstantopoulos The Interplay of the Physical Microenvironment, Contact Guidance and Intracellular Signaling in Cell Decision Making FASEB J 2016 link
124 S. Gerecht and K. Konstantopoulos Editorial overview: Biological Engineering: Engineering Systems for cancer modeling, diagnostics and therapeutics Current Opinion in Chemical Engineering 2016 no link
125 W-C Hung, J.R. Yang, C.L. Yankaskas, B.S Wong, P-H Wu, C. Pardo-Pastor, S.A. Serra, M-J Chiang, Z. Gu, D. Wirtz, M.A. Valverde, J.T. Yang, J. Zhang, and K Konstantopoulos Confinement-sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways Cell Reports 2016 link
126 M. Shriver, S. Marimuthu, C.D. Paul, J. Geist, T. Seale, K Konstantopoulos, and A. Kontrogianni-Konstantopoulos Giant obscurins regulate PI3K signaling in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit Oncotarget 2016 link
127 S. Curreli, B.S. Wong, O. Latinovic, K. Konstantopoulos and N.M. Stamatos Class 3 Semaphorins Induce F-Actin Reorganization in Human Dendritic Cells: Role in Cell Migration J Leuk Biol 2016 link
128 E. Mathieu, C.D. Paul, R. Stahl, G. Vanmeerbeeck, V. Reumers, C. Liu, K. Konstantopoulos*, and L. Lagae* Time-lapse lens-free imaging of cell migration in diverse physical microenvironments Lab on a Chip 2016 link
129 K.M. Stroka*, B.S. Wong, M. Shriver, A. Kontrogianni-Konstantopoulos, K. Konstantopoulos* Loss of Giant Obscurins Alters Breast Epithelial Cell Mechanosensing of Matrix Stiffness Oncotarget 2016 link
130 Colin D. Paul, Panagiotis Mistriotis and Konstantinos Konstantopoulos Cancer cell motility: lessons from migration in confined spaces Nature Reviews Cancer 2016 link
131 A. Jablonska, D.J. Shea, S. Cao, J.W.M. Bulte, M. Janowski, K. Konstantopoulos, P. Walczak Overexpression of VLA-4 in glial-restricted precursors enhances their endothelial docking and induces diapedesis in a mouse stroke model J Cerebral Blood Flow and Metabolism 2017 no link